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Patrick Arbuthnot

University of the Witwatersrand, South Africa

Biography

Patrick Arbuthnot is currently personal professor and director of the Wits/SAMRC Antiviral Gene Therapy Research Unit at the University of the Witwatersrand in South Africa. After graduating with a medical degree he completed a PhD in 1992 then carried out postdoctoral work at Necker Hospital in Paris, France. It was during this time that Dr Arbuthnot developed an interest in advancing gene therapy for treatment of liver cancer and hepatitis B virus (HBV) infection. On returning to South Africa, he established the Antiviral Gene Therapy Research Unit, which has now published widely on HBV infection, liver cancer, HIV-1 infection and developing new methods of treating these diseases. Patrick Arbuthnot’s main research interest is in advancing use of biological and synthetic nanoparticles to carry potentially therapeutic nucleic acids (DNA or RNA) that are capable of permanently disabling HBV.

Abstract

Abstract : Engineering sequence-specific transcriptional repressors to disable replication of hepatitis B virus