Reham Abo Elwafa
Alexandria University, Egypt
Title: Study of Alternative Wilms tumor gene methylation as an epigenetic biomarker in acute myeloid Leukemia
Biography
Biography: Reham Abo Elwafa
Abstract
Overexpression of the Wilms tumor 1 gene (WT1) is implicated in the prognosis of acute myeloid leukemia (AML) with high expression predicting disease progression, as well as being intensively studied as a potential molecular marker for minimal residual disease (MRD) and treatment response. Many different isoforms for WT1 are generated by alternative transcription initiation, mRNA splicing and alternative translation initiation. Recently, an alternative promoter incorporating a unique first exon, alternative WT1 transcript (AWT1), has been described. The AWT1 expression and the underlying epigenetic alterations associated with its expression in AML are still unknown.