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Makkuni Jayaram

University of Texas at Austin, USA

Biography

Makkuni Jayaram is a Professor of Molecular Biosciences at the University of Texas at Austin. His primary research interest is in the biochemical mechanisms of site-specific DNA recombination. Over the past three decades, his research group has used the Flp site-specific recombinase as a template for understanding the chemistry, conformational dynamics and topological features of strand breakage/exchange reactions in nucleic acids. A second interest of the Jayaram laboratory concerns strategies devised by selfish DNA elements for moderating their selfishness so as to establish long-term peaceful coexistence with their host genomes.

Abstract

Abstract : Stereochemical Course of Site-specific DNA Recombination Revealed by Methylphosphonate-substituted DNA substrates and active site variants of Flp and Cre Recombinases