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3rd International Conference on Molecular Biology & Nucleic Acids, will be organized around the theme “The Blueprint of Life”
Molecular Biology - Conference 2018 is comprised of 18 tracks and 48 sessions designed to offer comprehensive sessions that address current issues in Molecular Biology - Conference 2018.
Submit your abstract to any of the mentioned tracks. All related abstracts are accepted.
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Molecular Biology is the field of biology that studies the composition, structure and interactions of cellular molecules such as nucleic acids and proteins that carry out the biological processes essential for the cells functions and maintenance. Molecular Biology covers a wide scope of problems related to molecular and cell biology including structural and functional genomics, transcriptomics, proteomics, bioinformatics, biomedicine, molecular enzymology, molecular virology and molecular immunology, theoretical bases of biotechnology, physics and physical chemistry of proteins and nucleic acids.
- Track 1-1Computational Biology
- Track 1-2Cellular Biology
- Track 1-3Genetics
- Track 1-4Biosynthesis
- Track 1-5Transcription
- Track 1-6Microarray analysis techniques
Molecular biology techniques are regular procedures used in biochemistry, molecular biology, biophysics & genetics which generally involve manipulation & analysis of DNA, RNA, lipid & protein. Since around 1960, molecular biologists have developed different ways to identify, isolate & manipulate molecular components in cells including DNA, RNA & proteins.
- Track 2-1Molecular cloning
- Track 2-2Gel electrophoresis
- Track 2-3Polymerase chain reaction (PCR)
- Track 2-4Macromolecule blotting and probing
Sequencing is used in molecular biology to study genomes & the proteins they convert. Information obtained using sequencing allows researchers to identify changes in genes, associations with diseases and phenotypes, and identify potential drug targets.
A microarray is a laboratory tool used to detect the expression of thousands of genes at the same time. DNA microarrays are microscope slides that are printed with thousands of tiny spots in defined positions, with each spot containing a known DNA sequence or gene. Often, these slides are referred to as gene chips or DNA chips. The DNA molecules attached to each slide act as probes to detect gene expression, which is also known as the transcriptome or the set of messenger RNA (mRNA) transcripts expressed by a group of genes.
- Track 3-1DNA sequencing
- Track 3-2RNA sequencing
- Track 3-3Protein sequencing
- Track 3-4Applications of Microarray
- Track 3-5Interferometric reflectance imaging sensor
Thermodynamic properties of nucleic acids have attracted considerable attention since the early 1960s. Thermodynamics is very important in understanding the biological function of nucleic acids, such as DNA replication, mutation, repair and transcription and also to study how temperature affects the nucleic acid structure of double-stranded DNA (dsDNA).
- Track 4-1Annealing
- Track 4-2Denaturation
- Track 4-3Hybridization
- Track 4-4Melting point (Liquefaction Point)
- Track 4-5Western blot (Protein Immunoblot)
Molecular engineering involves the creation of molecules & the development of new products from them. Molecular engineering is highly interdisciplinary by nature, encompassing aspects of chemical engineering, bioengineering, materials science, electrical engineering, mechanical engineering, physics and chemistry. The field is particularly important for scientific materials research & pharmaceuticals, as it is employed as a sophisticated form of chemical engineering. Molecular engineering is a dynamic & evolving field with complex target problems; breakthroughs require sophisticated and creative engineers who are conversant across disciplines.
Molecular modelling includes all theoretical, methods and computational used to model or mimic the behaviour of molecules. The methods are used in the fields of drug design, computational biology, computational chemistry & materials science to study molecular systems ranging from small chemical systems to large biological molecules and material assemblies. Quick calculations can be achieved by hand, but inevitably supercomputers are required to perform molecular modelling of any reasonably sized system. The common feature of molecular modelling methods is the atomistic level description of the molecular systems. This may include treating atoms as the smallest individual unit or explicitly modelling electrons of each atom.
- Track 5-1Biological engineering
- Track 5-2Biomolecular engineering
- Track 5-3Chemical engineering
- Track 5-4Molecular mechanics
- Track 5-5Cheminformatics
- Track 5-6Molecular modeling on GPUs
Nucleic acid methods are the techniques used to study nucleic acids: DNA and RNA. Nucleotides can be separated into purines and pyrimidines. They are both primarily produced in the liver. They both contain a sugar and a phosphate, but have nitrogenous bases that are different sizes. Because of this, the two different groups are synthesized in different ways. However, all nucleotide synthesis requires the use of phosphoribosyl pyrophosphate (PRPP) which donates the ribose and phosphate necessary to create a nucleotide.
- Track 6-1Purification & Quantification
- Track 6-2Kinetics & Gene function
- Track 6-3Oligonucleotide synthesis
Molecular genetics is the part of biology that studies the functions & structure of genes at a molecular level & therefore employs methods of both molecular biology & genetics. The study of chromosomes & gene expression of an organism can give insight into heredity, mutations & genetic variation. This is beneficial in the study of developmental biology in understanding & treating genetic diseases.
- Track 7-1Techniques
- Track 7-2Gene therapy
- Track 7-3Genetic screens
- Track 7-4Clinical application
For this conference DNA Replication is the first & most vital topic to be discussed. DNA Replication which is the basis of biological inheritance starts with the division of a cell into two daughter cells and in this process a double stranded DNA molecule is copied to generate two identical copies of DNA. Researchers are continuing with genome wide studies in DNA Replication which is resulting in may novel research. Many Universities worldwide are carrying out researches in the field of DNA Replication and Genetic Recombination. Being specific are The Penn State University, The Rockefeller University, Massachusetts General Hospital, University of Washington where many capable and talented Scientists are working in this field.
- Track 8-1DNA replication in Prokaryote & Eukaryote
- Track 8-2DNA replication proteins
- Track 8-3Recombinant DNA Technology
- Track 8-4Molecular cloning
- Track 8-5Polymerase chain reaction (PCR)
DNA Damage and DNA Repair both terms are related with the maintenance of genome integrity. DNA Damage may lead to mutation and finally causing many serious diseases. The biochemical mechanisms of these pathways have been characterized and the impact of this work was recently highlighted by the selection of Tomas Lindahl, Aziz Sancar and Paul Modrich as the recipients of the 2015 Nobel Prize in Chemistry for their seminal work in defining DNA repair pathways. Currently University of Alabama, UNC School of Medicine, Emory University School of Medicine and Newcastle University are working on this field.
- Track 9-1DNA mutation & deamination
- Track 9-2Chemical modification of bases
- Track 9-3Strand breaks
- Track 9-4Medicine and DNA repair modulation
- Track 9-5DNA repair and cancer
RNA editing is a molecular technique through which certain cells can make discrete changes to specific nucleotide sequences within a RNA molecule after it has been generated by RNA polymerase. RNA editing has been observed in the RNA sequences of viruses, archaea and prokaryotes. RNA editing occurs in the cell nucleus and cytosol, as well as within mitochondria and plastids. In vertebrates, editing is rare & usually consists of a minor amount of changes to the sequence of affected molecules. Two types of small ribonucleic acid (RNA) molecules – microRNA (miRNA) and small interfering RNA (siRNA) – are central to RNA interference. The study of RNA interference incudes its variation among organisms, cellular mechanisms, biological functions like up regulation of genes, immunity, down regulation of genes and its applications in gene knockdown, functional genomics, medicine and biotechnology. The University of Albany situated at New York is rigorously involved towards all the novel research on RNA. The RNA Institute maintained by Paul Agris (University at Albany) is the best known platform for carrying out RNA analysis. Added to that, The RNA Society formed in 1993 facilitates sharing and dissemination of experimental results and emerging concepts in ribonucleic acid research.
- Track 10-1Editing by insertion or deamination
- Track 10-2RNA editing in viruses
- Track 10-3Cellular mechanism
- Track 10-4Biological functions
- Track 10-5Genome-scale screening
DNA & RNA Nanotechnology is recently developing field of bio-nano-technologies. DNA and RNA Nanotechnology link the gap between newest developments in nucleic acids, structural folding & biomaterial sciences. It links understanding of DNA/RNA molecular.
Recombinant DNA Technology is the joining of two different DNA molecules that are implanted into a host organism to produce new genetic recombination. Recombinant DNA technology has made many tasks easier for the Scientists such as isolation of one gene or any other segment of DNA, determination of nucleotide sequence, study of transcripts, mutation of transcripts and reinserting it into a living organisms thus giving rise to the concept of transgenic.
RNA splicing is a process in which introns are removed and exons are joined prior to translation. In other words, RNA splicing is modification of the nascent pre-messenger RNA (pre-mRNA) transcript. To address the questions and other aspects of mRNA synthesis and processing, many researchers turned to the study of DNA viruses that infect animal cells in culture. RNA processing refers to any alteration made to RNA between its transcription & its concluding function in the cell. These processing steps include the removal of extra sections of RNA, specific modifications of RNA bases, and modifications of the ends of the RNA. Being Specific, The University of Manchester, Yale Center for RNA science and Medicine, Rutgers University are working on this field for bringing out many challenging results.
Protein synthesis is one of the most fundamental biological processes by which individual cells build their specific proteins. Within the process are involved both DNA & different in their function ribonucleic acids (RNA). The process is initiated in the cell’s nucleus, where specific enzymes unwind the needed section of DNA, which makes the DNA in this region accessible and a RNA copy can be made. This RNA molecule then changes from the nucleus to the cell cytoplasm, where the definite process of protein synthesis occurs.
Molecular microbiology is the subdivision of microbiology devoted to the study of the molecular basis of the physiological processes that occur in microorganisms. A biologic is generally made in living cells which is made by adding a piece of DNA to a cell. The cell then produces protein by translating which work as biologic medicine. Generally post translational modifications are responsible for introducing the variability in biologics. Recently many challenging works are carried out in this field which will bring out a revolution in the field of molecular biology.
Computational molecular biology is a field which unites statistical, computational, technological & experimental methods, which is energizing & vividly accelerating the discovery of new technologies & tools for molecular biology. It deals with the main issues concerning analysis of sequences, genomes and structures. This introduces the simple computational methods used to understand the cell on a molecular level. It covers subjects such as the sequence alignment algorithms: hashing, dynamic programming, suffix trees, and Gibbs sampling. Furthermore, it focuses on computational approaches to: genetic & physical mapping; genome sequencing, assembly & annotation; RNA expression & secondary structure; protein structure & folding; and molecular interactions & dynamics.
Molecular & Cellular Medicine studies on five departments of health and disease: inflammatory & infectious disease, cancer, hereditary diseases, degenerative diseases & tissue engineering & regeneration.
Molecular medicine is a wide area, where physical, biological, chemical, bioinformatics & medical methods are used to describe mechanisms & molecular structures, identify central molecular & genetic errors of disease, and to develop molecular interferences to correct them. The molecular medicine perspective highlights cellular & molecular phenomena and interferences rather than the previous conceptual & observational focus on patients and their organs.
Cellular medicine is a wide range of biological procedures from structure & function of biomolecules to cell physiology to understand the irregular biological function at the cellular level. Cellular Medicine also describes an optimum regular intake of specific micronutrients as a basic preventative measure for maintaining health efficiently & safe control of many pathological conditions.
Personalized healthcare, based on the uniqueness of each patient’s individual condition, situation, and needs, is the key to achieving population health and value-based care goals. We view personalized healthcare as a broader platform that includes genetics and genomics but also includes any other biologic information that helps predict risk for disease or how a patient will respond to treatments. The example of personalized healthcare would be presence of precise biomarkers like lipoprotein that can help to well predict risk for heart disease or stroke in certain individuals. These biomarkers can augment our traditional means of evaluating risk based on age, menopausal status for women, high blood pressure, diabetes or high cholesterol levels.
Case report is a detailed description on rare diseases, novel occurrences, unusual indication or symptoms of a disease, unreported studies or unexpected events observed in a patient during the course of treatment. The study should highlight and report new cases in diagnosis of emerging diseases or specify variations and associations with new diseases. Case report should contain educational values and emphasize on the need of amendments to usual practices and approaches in the field. Case reports should include different findings with efficient review on previous cases & investigation in the field. There should not be any preventive & therapeutic interruptions in the Case reports from the findings since they need more confirmed evidences.