Nucleic Acids

DNA Repair Mechanism

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DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as UV light and radiation can cause DNA damage, resulting in as many as 1 million individual molecular lesions per cell per day. Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to transcribe the gene that the affected DNA encodes. Other lesions induce potentially harmful mutations in the cell's genome, which affect the survival of its daughter cells after it undergoes mitosis. As a consequence, the DNA repair process is constantly active as it responds to damage in the DNA structure. When normal repair processes fail, and when cellular apoptosis does not occur, irreparable DNA damage may occur, including double-strand breaks and DNA cross linkages .The rate of DNA repair is dependent on many factors, including the cell type, the age of the cell, and the extracellular environment. A cell that has accumulated a large amount of DNA damage, or one that no longer effectively repairs damage incurred to its DNA, can enter one of three possible states.

Relevant conferences: 

International Conference on Amino Acids and Proteins, December 08-09, 2016 Dallas, USA ; International Conference on Biochemistry, October 13-15, 2016 Kuala Lumpur, Malaysia; 13^th International Conference on Nanotek and Expo, December 05-07, 2016 Phoenix, USA; 8th International Conference on Proteomics, March 20-22, 2017 Philadelphia, USA;  2^nd International Conference on Genetic and Protein Engineering, November 14-16, 2016 Atlanta, USA; XXII International Roundtable on Nucleosides, Nucleotides and Nucleic Acids,
 on July 18-22, 2016 at Institut Pasteur, Paris, France; 5^th Zing Nucleic Acids Conference, December 02-05, 2016 Tampa, USA; 18^th International Conference on Nucleic Acids, January 07-08, 2016 Singapore; The 30^th Anniversary Symposium of the Protein Society, July 16-19, 2016 Baltimore, USA; RNA 2016, Kyoto, Japan