Nucleic Acids

Protein Regulatory Mechanism

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Protein modifications by formaldehyde treatment and histological processing have frustrated attempts to use FFPE tissues for proteomic analyses due to the difficulty in extracting representative proteins. Ubiquitin and Ubiquitin-like modifications are some of the examples. This limitation has restricted studies of diseases that evolve slowly or for those where the time between treatment and recurrence is long, such as prostate and breast cancer. The Multivesicular body and endocytosis are being studied for investigating these diseases. Coupling the medical history and pathology information from FFPE tissues with proteomic investigations would produce a wealth of practical information on important human diseases and will also unveil the Mechanisms of bacterial pathogenesis. Major change in the structure can be caused by Regulatory thiol modifications.

Relevant Conferences:  6^th International Conference & Expo on Proteomics, March 29-30, 2016 Atlanta, USA; World Congress on Amino Acids and Proteins, December 08-09, 2016 Baltimore, USA; 2^nd International Conference on Genetic and Protein Engineering, November 14-16, 2016 Atlanta, USA;  International Conference on Biochemistry, October 13-15, 2016 Kuala Lumpur, Malaysia; : 3^rd World Congress on Pharmacology, August 08-10, 2016 Birmingham, UK; Keystone Symposia on Ubiquitin Signaling (X3), March 13—17, 2016 Whistler, British Columbia, Canada; Gordon Research Conference on Intrinsically Disordered Proteins, June 26 - July 1, 2016 Les Diablerets, Switzerland; BITS 9^th Annual World Protein & Peptide Conference, April 25-28, 2016; International conference center,Dalian,China; Keystone Symposia on Neurological Disorders of Intracellular Trafficking (A7), January 31—February 4, 2016 Colorado, USA; ;  XXII International Roundtable on Nucleosides Nucleotides and Nucleic Acids,
 on July 18-22, 2016 at Institut Pasteur – Paris, France.